Adherencia al tratamiento en psiquiatría: estudio preliminar de los modelos empleados

En este trabajo, nos planteamos el estudio de en qué modelos prima la investigación de la adherencia al tratamiento en la clínica psiquiátrica, a partir del análisis de la producción científica registrada en un buscador de reconocido prestigio. A tal efecto, y en orden a responder al objetivo general planteado, se revisa la inclusión de dicho término en el reservorio Scopus (www.scopus.es), considerada la base de datos o buscador multidisciplinar por excelencia dentro del ámbito científico actual. De esta forma, se estudian en un período limitado a un lustro, las publicaciones editadas en revistas científicas internacionales desde la perspectiva de los modelos biológicos, psicológicos y sociales en Psiquiatría en los que enmarquen. Realizada la revisión bibliográfica pertinente, se aprecia el predominio de estudios desde los modelos psicológicos (16 publicaciones), desde los modelos sociales (14 resultados) frente a los trabajos en el que la adherencia al tratamiento en Psiquiatría se efectúa desde la perspectiva de los modelos biológicos (3 publicaciones). Finalmente, se propone incidir en el análisis detallado de la naturaleza de la adherencia al tratamiento entendiéndola en el marco de la misma relación médico-paciente, dirigiéndose el foco de atención hacia la investigación de la adherencia al tratamiento en el conjunto de las especialidades médicas y sanitarias y, atendiendo, específicamente, a determinadas poblaciones infanto-juveniles y de adultos. Igualmente, se sugiere la necesidad de ampliar el período de tiempo revisado y la adecuación de otros descriptores que fuesen más idóneos tal como se ha podido apreciar en esta investigación preliminar.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Assistive Technology for Elderly Care: An Overview

Global demographic changes have resulted in a growing technological demand to meet the arisen social needs. In particular, the increasingly ageing population requires assistive technologies to stay at home for longer independently while receiving continuous healthcare. In this sense, a wide academic and industrial research is taking place, introducing these technologies in hospitals and rehabilitation centres. This paper aims at providing an overview of research projects for elderly care and assistance, focusing on cognitive and robot assistants due to their popularity in the area. More precisely, physical and/or cognitive rehabilitation are presented. This paper also discusses their limitations and the open challenges to be tackled in order to be successfully integrated in our society

Disulphide production by Ero1alpha-PDI relay is rapid and effectively regulated

The molecular networks that control endoplasmic reticulum (ER) redox conditions in mammalian cells are incompletely understood. Here, we show that after reductive challenge the ER steady-state disulphide content is restored on a time scale of seconds. Both the oxidase Ero1alpha and the oxidoreductase protein disulphide isomerase (PDI) strongly contribute to the rapid recovery kinetics, but experiments in ERO1-deficient cells indicate the existence of parallel pathways for disulphide generation. We find PDI to be the main substrate of Ero1alpha, and mixed-disulphide complexes of Ero1 primarily form with PDI, to a lesser extent with the PDI-family members ERp57 and ERp72, but are not detectable with another homologue TMX3. We also show for the first time that the oxidation level of PDIs and glutathione is precisely regulated. Apparently, this is achieved neither through ER import of thiols nor by transport of disulphides to the Golgi apparatus. Instead, our data suggest that a dynamic equilibrium between Ero1- and glutathione disulphide-mediated oxidation of PDIs constitutes an important element of ER redox homeostasis

Socially Assistive Robots for Older Adults and People with Autism: An Overview

Over one billion people in the world suffer from some form of disability. Nevertheless, according to the World Health Organization, people with disabilities are particularly vulnerable to deficiencies in services, such as health care, rehabilitation, support, and assistance. In this sense, recent technological developments can mitigate these deficiencies, offering less-expensive assistive systems to meet users’ needs. This paper reviews and summarizes the research efforts toward the development of these kinds of systems, focusing on two social groups: older adults and children with autism.This research was funded by the Spanish Government TIN2016-76515-R grant for the COMBAHO project, supported with Feder funds. It has also been supported by Spanish grants for PhD studies ACIF/2017/243 and FPU16/00887